If you want to play with a six, put a built up 300 truck engine in with supercharging. Should be able to get 1 hp per cu in. +. And yes it will fit.
The 200 and the 250 have the same 3.68" bore but the 250 has a 3.91" stroke vs the 3.12" stroke of the 200. With seven mains, the engine can handle a fair amount of power, but an upgrade to better rod and main bolts would be necessary for an extreme turbo application. It should be capable of handling 300 hp with the proper attention to the combination. The 250 is almost 2" taller than the 200, making it difficult to install in a lot of cars, especially early Mustangs. A 300 would be a neat idea, but it's even bigger (longer, taller) making it tough to package. It can be done, though. You can certainly turbo a carbed engine, but tuning an EFI is a lot easier, especially when you have full control over timing and fule maps. If you spend many thou$and$ on building a strong enough engine to handle a lot of boost, why would you skimp on fuel and ignition control? Boost and EFI were made for each other! Hope you have deep pockets, though!
It really sounds like a 200 would be a great canidate for a turbo charger with the shorter stroke. I could see using H-beam rods, and forged aluminum low compression pistons as a good move for geting the quick and high rpms turbos love. Are Mav lifters hydraulic or solid?