After 5 years of use without issues.. I'd say you are gonna be fine over the long run. High output/high cylinder pressure motors are much less forgiving to guide wear than the lo-po factory stuff.
I put headers on the 250 six took the head off and machine the top of the intake manifold to adapt an Offenhauser 3 carb intake blocked the center carb and ran the end 2 carbs so 2 one barrel carbs and headers and it eats stock 302s and gets better gas mileage
This is a really useful thread. Back in the late 80s, we had a '72 Comet with a 200 that otherwise ran great but fouled plugs. On road trips, we had to pull and clean the plugs every fuel stop. On a round-trip from San Francisco to New York, we got so good at changing plugs we could do it in under five minutes.